Interlinked Premium·Monday, March 30, 2026

The bioavailability gap: oral vs. IV vitamin C

By Alfred Belvedere — Founder, Omni AI

11 tags

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"Bioavailability is just a fancy word for 'what your body actually got.'"

Vitamin C is the test case that reveals everything you need to know about the difference between oral supplementation and IV therapy. The same molecule, the same dose, two completely different stories depending on the route.

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Oral vitamin C absorption is capped by transporter saturation in the small intestine — typically around two hundred milligrams per dose. Push past that and the rest passes through; you can't bulk your way around the cap. The body has decided that's enough, and it's decided that for a reason.

IV vitamin C bypasses the intestinal cap entirely. Plasma concentrations from a ten-gram IV dose run twenty to seventy times what you can achieve orally — and the literature on what those concentrations do at the cellular level (immune function, oxidative load, even adjuvant cancer-care research) is real and growing.

High-dose IV vitamin C isn't for everyone or every situation. We screen for G6PD deficiency, kidney function, and iron-overload conditions before pushing past five grams. The gap matters; using it responsibly matters more.

Power Move

If you're fighting a cold, take eight to ten grams oral spread across the day plus a single IV push. The combo gets you both the systemic plasma elevation and the ongoing low-dose flow.