Interlinked Premium·Sunday, February 15, 2026

NAD+ explained without the longevity hype

By Alfred Belvedere — Founder, Omni AI

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"I expected to feel ten years younger. I felt rested for the first time in six weeks. That was enough."

NAD+ might be the most-marketed molecule in wellness right now. The science is real and interesting; most of the marketing around it is not. Here's the clinical story we tell when somebody asks whether it's worth their time.

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NAD+ is a coenzyme involved in roughly five hundred enzymatic reactions, most of them inside the mitochondria. Levels decline measurably with age — that part is settled. What's less settled is how much restoring intracellular NAD+ via IV translates to outcomes you'd actually feel. The honest answer: for some people, a lot. For others, less than the price tag suggests.

Dose and duration matter more than frequency. Two-fifty milligrams over two hours is the entry-level protocol; serious longevity-curious clients run five hundred to a thousand milligrams over four to six hours. The slow drip rate isn't for theatre — push too fast and the side effects (chest pressure, abdominal discomfort) walk most people out of the chair.

NAD+ pairs poorly with caffeine and well with stillness. We tell every NAD+ client to clear their afternoon and bring something to read or watch. The clients who try to squeeze it in between meetings rarely come back; the clients who treat it as a long quiet block usually do.

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Try a single two-fifty session before committing to a longer protocol. The first session tells you whether your body is in the high-responder or low-responder population.